Oestrogel contains oestradiol and is a hormone replacement therapy used to relieve menopausal symptoms such as hot flushes, night sweats and vaginal dryness. Apply the gel exactly as prescribed to clean, dry skin and allow it to dry completely before dressing. Common side effects include headache, breast tenderness, nausea and skin irritation. Attend regular reviews and seek urgent medical advice if you develop symptoms of a blood clot.