Elleste is a hormone replacement therapy (HRT) containing oestradiol to help relieve menopausal symptoms such as hot flushes, night sweats, mood changes and vaginal dryness. Take it exactly as prescribed and attend regular medication reviews. Common side effects include headache, breast tenderness, nausea and irregular bleeding during the first few months. Seek medical advice immediately if you experience chest pain, leg swelling or sudden shortness of breath.